SBI Pharmaceuticals Co., Ltd., (Head office: Minato-ku, Tokyo; Representative Director & President: Yoshitaka Kitao; “SBI Pharmaceuticals”), a subsidiary of SBI Holdings, Inc., engaged in research and development of pharmaceuticals, healthy foods, and cosmetics using 5-aminolevulinic acid (5-ALA) *, Graduate School of Science, Tokyo Metropolitan University (Hachioji City, Tokyo; President: Takaya Ohashi) and Department of Neurogenetics, National Center for Geriatrics and Gerontology (Obu City, Aichi; President: Hidenori Arai) hereby announce the publication of a research article entitled “5- aminolevulinic acid and sodium ferrous citrate improves muscle aging and extend healthspan in Drosophila” in an international academic journal, FEBS Open Bio.
| Journal： | FEBS Open Bio |
| Title： | 5-Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila |
| URL： | https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13338 |
| Abstract： | Declines in mitochondrial functions are associated with aging. The combination of 5-ALA and sodium ferrous citrate (SFC) increases mitochondrial activity in cultured cells. In this study, we investigated the effects of dietary supplementation with 5-ALA hydrochloride /SFC on the healthspan and lifespan of Drosophila melanogaster. Adult Drosophila fruit flies were fed cornmeal food containing various concentrations of 5-ALA hydrochloride combined with SFC. We found that feeding 5-ALA/SFC preserved muscle architecture and maintained the mitochondrial membrane potential in aged animals. Moreover, 5-ALA/SFC mitigated age-associated declines in locomotor functions and extended organismal lifespan. |
These results revealed a novel mechanism of action by which 5-ALA/SFC benefits physical functions and protects against aging in Drosophila.
(*) 5-aminolevulinic acid: An amino acid produced in mitochondria. It is an important substance that serves as a functional molecule related to energy production in the form of heme and cytochromes, and its productivity is known to decrease with age. 5-aminolevulinic acid is contained in food such as shochu lees, red wine and Asian ginseng. It is also known as a material forming chloroplasts in plants.
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For further information, please contact:
SBI Pharmaceuticals Co., Ltd.
E-mail: info_ala@sbigroup.co.jp
Tokyo Metropolitan University
Planning & Public Relations Division
TEL：+81 42 677 1806 E-mail : info@jmj.tmu.ac.jp
Associate Professor Kanae Ando
E-mail: k_ando@tmu.ac.jp
National Center for Geriatrics and Gerontology
Public relations: Ryo Satomura
Tel: +81 562-46-2311 E-mail: r-satomura@ncgg.go.jp
Chief: Koichi M. Iijima, PhD
Tel: +81 562-46-2311 E-mail: iijimakm@ncgg.go.jp
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